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(7-Diethylaminocoumarin-3-yl)carbonyl-Amyloid  β-Protein (1-40)
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(7-Diethylaminocoumarin-3-yl)carbonyl-Amyloid  β-Protein (1-40)

Code: DC160071(71)
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(7-Diethylaminocoumarin-3-yl)carbonyl-Amyloid  β-Protein (1-40)

Company Serial NumberDC160071(71)

Product Name(7-Diethylaminocoumarin-3-yl)carbonyl-Amyloid  β-Protein (1-40)

Synonym DAC-Amyloid ß-Protein (1-40)


Sequence(three-letter)(7-Diethylaminocoumarin-3-yl)carbonyl-Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Val-OH  Trifluoroacetate salt

Sequence(one-letter) (7-Diethylaminocoumarin-3-yl)carbonyl-DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVV-OHTrifluoroacetatesalt

Constitutional Formula

Molecular Formula C208H308N54O61S

Molecular Weight4573.13

References A.Kakio et al., J. Biol. Chem., 27, 24985 (2001)
 A.Kakio et al., Biochemistry, 41, 7385 (2002)
 A.Kakio et al., J. Pept. Sci., 10, 612 (2004)
 K.Ikeda and K.Matsuzaki, Biochem. Biophys. Res. Commun., 370, 525 (2008)

IllustrationAmyloid  β-protein (1-40) that is N-terminally modified with the fluorescent dye  (7-diethylaminocoumarin-3-yl)carbonyl (DAC or DEAC). This derivative can be  utilized to assess the binding properties of amyloid β-protein (1-40) for  various membranes since it behaves very similar to the native peptide. In  aqueous environments the fluorophor is almost non-fluorescent whereas binding  to membranes results in an increase in fluorescence intensity (λex = 430 nm,  λem = 470 nm). Increases in the GM1 ganglioside and cholesterol content in  the lipid bilayers facilitated the binding of this peptide. For  phosphatidylcholine and phosphatidylserine no affinity was observed.

Condition Of Storage: -20 ± 5 °C


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