上海德翅生物科技有限公司

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(Lys22)-Amyloid β-Protein (1-40)
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(Lys22)-Amyloid β-Protein (1-40) 
编号: DC160032(32)
CSA号: 302905-01-7
产品详情

(Lys22)-Amyloid β-Protein (1-40)

CompanySerial NumberDC160032(32)

ProductName(Lys22)-Amyloid β-Protein(1-40)

Synonym Amyloidβ-Protein (1-40) Italian Mutation, Amyloid β-Protein (1-40) E22K

CASNo.[302905-01-7] net

Sequence(three-letter)H-Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Lys-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Val-OHTrifluoroacetate salt

Sequence(one-letter) DAEFRHDSGYEVHHQKLVFFAKDVGSNKGAIIGLMVGGVV-OHTrifluoroacetatesalt

ConstitutionalFormula

MolecularFormula C195H300N54O56S

MolecularWeight4328.92

References S.Tsubukiet al., Lancet, 351, 1957 (2003)
L.Morelli et al., J. Biol. Chem., 278, 23221 (2003)
Y.Masuda et al., Bioorg. Med. Chem., 13, 6803 (2005)
V.Betts et al., Neurobiol. Dis., 31, 442 (2008)

IllustrationTheItalian mutation of β-amyloid 1-40 (E22K) aggregates more rapidly than the"wild-type" sequence 1-40. It showed increased neurotoxicity, which(according to a solid-phase NMR-study of Masuda et al.) may be due to the saltbridge formed between Lys22 and Asp23 in the minor conformer. As the Arctic,Flemish, and Dutch mutants, the Italian mutant is degraded considerably moreslowly than wild-type Aβ by neprilysin.

ConditionOf Storage: -20± 5 °C

本产品仅供研发使用,不能用于人体


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