上海德翅生物科技有限公司

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(Gly21)-Amyloid β-Protein (1-40)
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(Gly21)-Amyloid β-Protein (1-40) 
编号: DC160030(30)
CSA号: 154362-03-5
产品详情

(Gly21)-Amyloid β-Protein (1-40)

CompanySerial NumberDC160030(30)

ProductName(Gly21)-Amyloid β-Protein(1-40)

Synonym Amyloidβ-Protein (1-40) Flemish Mutation, Amyloid β-Protein (1-40) A21G

CASNo.[154362-03-5] net

Sequence(three-letter)H-Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Gly-Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Val-OHTrifluoroacetate salt

Sequence(one-letter) DAEFRHDSGYEVHHQKLVFFGEDVGSNKGAIIGLMVGGVV-OHTrifluoroacetatesalt

ConstitutionalFormula

MolecularFormula C193H293N53O58S

MolecularWeight4315.84

References Z.Wanget al., Stroke, 31, 534 (2000)
D.M.Walsh et al., Biochem. J., 355, 869 (2001)
S.Kumar-Singh et al., Neurobiol. Dis., 11, 330 (2002)
S.Tsubuki et al., Lancet, 351, 1957 (2003)
V.Betts et al., Neurobiol. Dis., 31, 442 (2008)
A.Jan et al., Nat. Protoc., 5, 1186 (2010)

IllustrationContraryto β-amyloid peptides mutated at position 22 (Dutch, Italian, Arctic mutants)the Flemish mutation (A21G) shows a decreased tendency to aggregate and areduced neurotoxicity. In the studies of Betts and Tsubuki, A21G was degradedsignificantly more slowly by neprilysin than the wild-type Aβ (1-40) and theE22 mutants. The relative resistance to proteolytic degradation may account forthe pathogenicity of the Aβ mutant.

ConditionOf Storage: -20± 5 °C

本产品仅供研发使用,不能用于人体


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