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(Gln22)-Amyloid β-Protein (1-40)
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(Gln22)-Amyloid β-Protein (1-40) 
编号: DC160029(29)
CSA号: 144410-00-4
产品详情

(Gln22)-Amyloid β-Protein (1-40)

CompanySerial NumberDC160029(29)

ProductName(Gln22)-Amyloid β-Protein(1-40)

Synonym Amyloidβ-Protein (1-40) Dutch Mutation, Amyloid β-Protein (1-40) E22Q

CASNo.[144410-00-4] net

Sequence(three-letter)H-Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Gln-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Val-OHTrifluoroacetate salt

Sequence(one-letter) DAEFRHDSGYEVHHQKLVFFAQDVGSNKGAIIGLMVGGVV-OHTrifluoroacetatesalt

ConstitutionalFormula

MolecularFormula C194H296N54O57S

MolecularWeight4328.88

References A.K.Sianet al., Biochem. J., 349, 299 (2000)
L.Miravalle et al., J. Biol. Chem., 275, 27110 (2000)

Z.Wanget al., Stroke, 31, 534 (2000)
S.Kumar-Singh et al., Neurobiol. Dis., 11, 330 (2002)
F.J.Mu?oz et al., J. Neurosci., 22, 3081 (2002)
R.Solito et al., Exp. Cell Res., 315, 385 (2009)
A.Jan et al., Nat. Protoc., 5, 1186 (2010)

IllustrationTheDutch mutation (E22Q) of amyloid β-peptide aggegates more readily than thewild-type peptide and the resulting fibrils show increased neurotoxicity. Themutant peptide E22Q induced apoptosis of cerebral endothelial cells at aconcentration of 25 μm, whereas WT Aβ (1-40) and the Italian mutant E22K(H-6698) showed no effect.

ConditionOf Storage: -20± 5 °C

本产品仅供研发使用,不能用于人体


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