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Amyloid β-Protein (1-40)
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Amyloid β-Protein (1-40)
编号: DC160022
CSA号: 131438-79-4
产品详情

Amyloid β-Protein (1-40)

CompanySerial NumberDC160022

ProductNameAmyloid β-Protein (1-40)

Synonym

CASNo.[131438-79-4] net

Sequence(three-letter)H-Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Val-OHTrifluoroacetate salt

Sequence(one-letter) DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVV-OHTrifluoroacetatesalt

ConstitutionalFormula

MolecularFormula C194H295N53O58S

MolecularWeight4330.09

References B.A.Yankneret al., Science, 250, 279 (1990)
M.A.Kowalska and K.Badellino, Biochem. Biophys. Res. Commun., 205, 1829 (1994)
A.Klegeris et al., Biochem. Biophys. Res. Commun., 199, 984 (1994)
M.Pitschke et al., Nat. Med., 4, 832 (1998)
G.Bitan et al., Proc. Natl. Acad. Sci. USA, 100, 330 (2003)
D.M.Walsh and D.J.Selkoe, J. Neurochem., 101, 1172 (2007)
A.Jan et al., Nat. Protoc., 5, 1186 (2010)

IllustrationAmyloidβ-protein (1-40) showed both neurotrophic and neurotoxic effects in dependenceon the neuronal age and the concentration of the β-protein. Aβ 1-40 has beenused as well as Aβ 1-42 to detect amyloid β-protein multimers in thecerebrospinal fluid of Alzheimer's disease patients. H-2972, the inverted Aβ1-40 sequence, can be used as inactive control in experiments employing H-1194.For detailed descriptions of the preparation of wild-type and mutant Aβ 1-40monomers and protofibrils please see the paper of Jan, Hartley, and Lashuel.

ConditionOf Storage: -20± 5 °C

本产品仅供研发使用,不能用于人体


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