上海德翅生物科技有限公司

Shanghai Dechi Biosciences Co,Ltd
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TAT peptide
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TAT peptide 
编号: DC164004
产品详情

TAT peptide

Company Serial NumberDC164004

Product NameTAT  peptide

Synonym

CAS No.

Sequence(three-letter)H-Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-NH2

Sequence(one-letter) H-YGRKKRRQRRR-NH2

Constitutional Formula

Molecular Formula C64H119N33O13

Molecular Weight1558.88 g/mol

References The TAT peptide (GRKKRRQRRRPQ) is derived from the  transactivator of transcription (TAT) of human immunodeficiency virus and is  a Cell-penetrating peptides. Cell-penetrating peptides (CPPs) have been used  to overcome the lipophilic barrier of the cellular membranes and deliver  large molecules and even small particles inside the cell for their biological  actions. CPPs are being used to deliver inside cell a large variety of  cargoes such as proteins, DNA, antibodies, contrast (imaging) agents, toxins,  and nanoparticular drug carriers including liposomes.

Illustration1.Simeoni,  F, Morris, MC, Heitz, F and Divita, G (2003). Insight into the mechanism of  the peptide-based gene delivery system MPG: implications for delivery of  siRNA into mammalian cells. Nucleic Acids Res 31: 2717–2724. 2.Tönges, L,  Lingor, P, Egle, R, Dietz, GP, Fahr, A and Bähr, M (2006). Stearylated  octaarginine and artificial virus-like particles for transfection of siRNA  into primary rat neurons. RNA 12: 1431–1438. 3.Morris, MC, Vidal, P, Chaloin,  L, Heitz, F and Divita, G (1997). A new peptide vector for efficient delivery  of oligonucleotides into mammalian cells. Nucleic Acids Res 25: 2730–2736.  4.Andaloussi, SE, Lehto, T, Mäger, I, Rosenthal-Aizman, K, Oprea, II,  Simonson, OE et al. (2011). Design of a peptide-based vector, PepFect6, for  efficient delivery of siRNA in cell culture and systemically in vivo. Nucleic  Acids Res 39: 3972–3987. 5.Eguchi, A, Meade, BR, Chang, YC, Fredrickson, CT,  Willert, K, Puri, N et al. (2009). Efficient siRNA delivery into primary  cells by a peptide transduction domain-dsRNA binding domain fusion protein.  Nat Biotechnol 27: 567–571. 6.Lundberg, P, El-Andaloussi, S, Sütlü, T, Johansson,  H and Langel, Ű (2007). Delivery of short interfering RNA using endosomolytic  cell-penetrating peptides. FASEB J 21: 2664–2671.

Condition Of Storage: Store at -20°C

本产品仅供研发使用,不能用于人体


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