Amyloid β/A4 Protein Precursor770 (740-770)

CompanySerial Number：DC160006

ProductName：Amyloid β/A4 ProteinPrecursor770 (740-770)

Synonym： APP770(740-770), C31

CASNo.：

Sequence(three-letter)：H-Ala-Ala-Val-Thr-Pro-Glu-Glu-Arg-His-Leu-Ser-Lys-Met-Gln-Gln-Asn-Gly-Tyr-Glu-Asn-Pro-Thr-Tyr-Lys-Phe-Phe-Glu-Gln-Met-Gln-Asn-OHTrifluoroacetate salt

Sequence(one-letter)： AAVTPEERHLSKMQQNGYENPTYKFFEQMQN-OHTrifluoroacetatesalt

ConstitutionalFormula：

MolecularFormula： C162H243N45O52S2

MolecularWeight：3717.12

References： D.C.Luet al., Nat. Med., 6, 397 (2000)
C.Dumanchin-Njock et al., J. Neurochem., 78, 1153 (2001)
V.Galvan et al., J. Neurochem., 82, 283 (2002)
D.C.Lu et al., J. Neurochem., 87, 733 (2003)
Y.Chen et al., J. Cell Biol., 163, 27 (2003)

Illustration：Amyloidβ/A4 Protein Precursor770 (740-770) corresponds to a C-terminal amyloidprecursor protein (APP) fragment known as C31. This fragment is intracellularlygenerated by proteolytic cleavage of APP by caspases-8 and -9. C31 had a proapoptoticand a cytotoxic effect on neuronal cells and was shown to be present in brainsof Alzheimer's disease (AD) patients. In cultured cells caspase cleavage of APPwas induced by amyloid β-protein and the subsequent generation of C31contributed to the apoptotic cell death associated with amyloid β-protein.Amyloid precursor binding protein BP1 (APP-BP1) a cell cycle protein which isincreased in AD brain was demonstrated to bind to the C31 region of APP and tomediate APP-induced apoptosis.

ConditionOf Storage: -20± 5 °C

★ 本产品仅供研发使用，不能用于人体